{"id":2184,"date":"2017-08-01T13:59:18","date_gmt":"2017-08-01T13:59:18","guid":{"rendered":"http:\/\/cytologystuff1.wpengine.com\/1587-2\/radiation-gallery\/"},"modified":"2025-02-10T20:04:54","modified_gmt":"2025-02-10T20:04:54","slug":"radiation-gallery","status":"publish","type":"page","link":"https:\/\/cytologystuff.com\/it\/1587-2\/radiation-gallery\/","title":{"rendered":"Radiation Gallery"},"content":{"rendered":"

[vc_row 0=””][vc_column 0=”” offset=”vc_hidden-lg vc_hidden-md”][vc_raw_html 0=””]JTNDY2VudGVyJTNFJTNDYSUyMGNsYXNzJTNEJTIyc2hpZnRuYXYtdG9nZ2xlJTIwc2hpZnRuYXYtdG9nZ2xlLWJ1dHRvbiUyMiUyMGRhdGEtc2hpZnRuYXYtdGFyZ2V0JTNEJTIyc2hpZnRuYXYtbWFpbiUyMiUzRSUzQ2klMjBjbGFzcyUzRCUyMmZhJTIwZmEtYmFycyUyMiUzRSUzQyUyRmklM0UlMjBUYWJsZSUyMG9mJTIwQ29udGVudHMlMjAlM0MlMkZhJTNFJTNDJTJGY2VudGVyJTNF[\/vc_raw_html][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Radiation Gallery” font_container=”tag:h1|text_align:center” use_theme_fonts=”yes”][\/vc_column][\/vc_row][vc_row][vc_column width=”2\/3″][vc_column_text]<\/p>\n

\n

<\/a>
\n Discussion <\/strong>
\nRadiation treatment of malignant lesions in the female genital tract traumatizes the epithelium causing ulceration that can cytologically mimic dysplasia or carcinoma. The extent of this trauma depends on the type and duration of therapy, therefore the cellular changes may resolve within six months or can persist for a lifetime. Some chemotherapeutic agents can also produce similar cellular changes, making patient history a valuable tool. Post-radiation dysplasia (PRD) has been reported in up to 23% of patients with the atypia resembling that of non-radiated patients. Considering the difficulties in distinguishing PRD from recurrent carcinoma, colposcopy and biopsy are recommended to rule out the latter.<\/p>\n

Cytology<\/strong>
\nCytomegaly is the most well known radiation related change. Cytomegalic cells have enlarged and\/or multiple nuclei and abundant cytoplasm while maintaining a fairly normal N\/C ratio. The nuclei can be pale and the chromatin can be finely granular to “smudgy” with possible micro- and macronucleoli and vacuoles. The cytoplasm may exhibit bichromasia and vacuoles with or without engulfed polys. Bizarre cell shapes may also be seen. The background of these specimens will contain degenerated blood that appears “stringy”, cellular debris, polys and histiocytes. Reparative changes can be seen frequently and occur in single-layered, cohesive, streaming sheets with pale nuclei and prominent nucleoli. Radiated fibroblasts are present and have delicate cytoplasm with vacuoles and cytoplasmic projections. The nuclei are pale, finely granular with possible nucleoli. Degenerated tumor cells may be seen in specimens initially following radiation.<\/p>\n

Reminder: You may click on any slide image
\nfor an enlarged view.<\/strong><\/p>\n

\n\"Image<\/a><\/p>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell with multiple enlarged nuclei and abundant cytoplasm. Compare size with normal cells.
\n20x<\/div>\n<\/div>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell with multiple enlarged nuclei and abundant cytoplasm. Compare size with normal cells.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell exhibiting bichromasia and multiple cytoplasmic vacuoles.
\n20x<\/div>\n<\/div>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell exhibiting bichromasia and multiple cytoplasmic vacuoles.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Bizarre cells<\/strong>
\nBizarre cells forms with ingested polys. Note the irregular macronucleolus.
\n20x<\/div>\n<\/div>\n
Bizarre cells<\/strong>
\nBizarre cells forms with ingested polys. Note the irregular macronucleolus.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell and bizarre cell forms in an inflammatory background.
\n10x<\/div>\n<\/div>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell and bizarre cell forms in an inflammatory background.
\n10x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell due to radiation. Compare cell size to surrounding polys.
\n20x<\/div>\n<\/div>\n
Cytomegalic cell<\/strong>
\nCytomegalic cell due to radiation. Compare cell size to surrounding polys.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Reparative changes<\/strong>
\nReparative changes in single-layered, streaming sheet. Note the pale chromatin and nucleoli.
\n20x<\/div>\n<\/div>\n
Reparative changes<\/strong>
\nReparative changes in single-layered, streaming sheet. Note the pale chromatin and nucleoli.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Radiation changes<\/strong>
\nRadiation changes present in an inflammatory background.
\n20x<\/div>\n<\/div>\n
Radiation changes<\/strong>
\nRadiation changes present in an inflammatory background.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Radiation changes<\/strong>
\nRadiation changes in a debritous, bloody background with a “stringy” appearance.
\n20x<\/div>\n<\/div>\n
Radiation changes<\/strong>
\nRadiation changes in a debritous, bloody background with a “stringy” appearance.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Fibroblast<\/strong>
\nFibroblast with pale chromatin, nucleolus and delicate cytoplasm.
\n40x<\/div>\n<\/div>\n
Fibroblast<\/strong>
\nFibroblast with pale chromatin, nucleolus and delicate cytoplasm.
\n40x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Group of fibroblasts<\/strong>
\nGroup of fibroblasts. Note the cytoplasmic projections.
\n20x<\/div>\n<\/div>\n
Group of fibroblasts<\/strong>
\nNote the cytoplasmic projections.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Fibroblasts<\/strong>
\nHigher power view of fibroblasts seen above. The chromatin is pale and finely granular.
\n60x<\/div>\n<\/div>\n
Fibroblasts<\/strong>
\nHigher power view of fibroblasts seen above. The chromatin is pale and finely granular.
\n60x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Squamous cell carcinoma<\/strong>
\nSquamous cell carcinoma present in a post-radiation specimen. Note the “stringy” background.
\n20x<\/div>\n<\/div>\n
Squamous cell carcinoma<\/strong>
\nSquamous cell carcinoma present in a post-radiation specimen. Note the “stringy” background.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Squamous cell carcinoma<\/strong>
\nHigher magnification of group shown above. Varying cell sizes and shapes with irregular nuclear borders and projections. Prominent nucleoli are present.
\n60x<\/div>\n<\/div>\n
Squamous cell carcinoma<\/strong>
\nHigher magnification of group shown above. Varying cell sizes and shapes with irregular nuclear borders and projections. Prominent nucleoli are present.
\n60x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Squamous cell carcinoma<\/strong>
\nA different group of post-radiation Squamous cell carcinoma.
\n60x<\/div>\n<\/div>\n
Squamous cell carcinoma<\/strong>
\nA different group of post-radiation Squamous cell carcinoma.
\n60x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Adenocarcinoma<\/strong>
\nAdenocarcinoma in a post-radiation ThinPrep. Prominent nucleoli and varied nuclear size can be seen at low power.
\n20x<\/div>\n<\/div>\n
Adenocarcinoma<\/strong>
\nAdenocarcinoma in a post-radiation ThinPrep. Prominent nucleoli and varied nuclear size can be seen at low power.
\n20x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Adenocarcinoma<\/strong>
\nHigher power view of group above. Note the irregular nucleoli, clumped chromatin and varied nuclear size.
\n40x<\/div>\n<\/div>\n
Adenocarcinoma<\/strong>
\nHigher power view of group above. Note the irregular nucleoli, clumped chromatin and varied nuclear size.
\n40x<\/div>\n
<\/div>\n

\n\"Image<\/a><\/p>\n
Nuclear irregularites<\/strong>
\nNuclear irregularities can be further appreciated. Some cells have multiple nucleoli.
\n60x<\/div>\n<\/div>\n
Nuclear irregularites<\/strong>
\nNuclear irregularities can be further appreciated. Some cells have multiple nucleoli.
\n60x<\/div>\n<\/div>\n
<\/div>\n

References<\/strong><\/p>\n

    \n
  1. Atkinson\/Silverman: Atlas of Difficult Diagnoses in Cytopathology, 1998: 32, 57, 69, 79, 105.<\/li>\n
  2. DeMay, R: Practical Principles of Cytopathology, 1999: 17.<\/li>\n
  3. Nguyen\/Kline: Essentials of Exfoliative Cytology, 1992: 101-108.<\/li>\n<\/ol>\n

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    [vc_row 0=””][vc_column 0=”” offset=”vc_hidden-lg vc_hidden-md”][vc_raw_html 0=””]JTNDY2VudGVyJTNFJTNDYSUyMGNsYXNzJTNEJTIyc2hpZnRuYXYtdG9nZ2xlJTIwc2hpZnRuYXYtdG9nZ2xlLWJ1dHRvbiUyMiUyMGRhdGEtc2hpZnRuYXYtdGFyZ2V0JTNEJTIyc2hpZnRuYXYtbWFpbiUyMiUzRSUzQ2klMjBjbGFzcyUzRCUyMmZhJTIwZmEtYmFycyUyMiUzRSUzQyUyRmklM0UlMjBUYWJsZSUyMG9mJTIwQ29udGVudHMlMjAlM0MlMkZhJTNFJTNDJTJGY2VudGVyJTNF[\/vc_raw_html][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=”Radiation Gallery” font_container=”tag:h1|text_align:center” use_theme_fonts=”yes”][\/vc_column][\/vc_row][vc_row][vc_column width=”2\/3″][vc_column_text] Discussion Radiation treatment of malignant lesions in the female genital tract traumatizes the epithelium causing ulceration that can cytologically mimic dysplasia or carcinoma. The extent of this trauma depends on the type and duration of therapy, therefore the cellular changes may resolve within six<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":1672,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-2184","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/pages\/2184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/comments?post=2184"}],"version-history":[{"count":0,"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/pages\/2184\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/pages\/1672"}],"wp:attachment":[{"href":"https:\/\/cytologystuff.com\/it\/wp-json\/wp\/v2\/media?parent=2184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}